Biomechanical stress and estrogen impact on human osteoblasts

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The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts

Hydrogen sulfide (H2S), generated in the osteoblasts predominantly via cystathionine-γ-lyase (CSE), is bone protective. Previous studies suggested that the onset of bone loss due to estrogen deficiency is associated to decreased levels of H2S and blunted gene expression of CSE. However, there are still a lot of unknowns on how H2S levels influence bone cells function. The present study aims to ...

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ژورنال

عنوان ژورنال: Osteoarthritis and Cartilage

سال: 2012

ISSN: 1063-4584

DOI: 10.1016/j.joca.2012.02.139